Objective:To analyze the effect of multidisciplinary cooperation mode and peer support on self-protection awareness,hope level and quality of life of amputees with diabetes foot gangrene.Methods:Retrospective analysis was used to study 146 amputees with foot gangrene of diabetes.Among them,58 patients from October 2022 to September 2023 were given routine clinical intervention and included in the control group,the remaining 88 patients from October 2023 to September 2024 were given multidisciplinary collabo-ration mode combined with peer support intervention and included in the observation group.Assess the self-protection awareness,hope,coping strategies,and quality of life were compared between the two groups.Results:There was no significant difference in the self-pro-tection awareness score,hope scale score,coping style score,and quality of life score between the two groups before intervention(P>0.05).After intervention,the observation group had higher scores in self-awareness,self responsibility,self-protection skills,health knowledge level,positive attitude,excessive behavior,intimate relationship score,physiological function,physiological function,physical symptoms,general health status,energy,emotional function,mental health,and social function than the control group(P<0.05).After intervention,the avoidance and surrender scores of the observation group were lower than those of the control group,and the face score was higher than that of the control group(P<0.05).Conclusion:The multidisciplinary cooperation mode combined with peer support intervention can improve the self-protection awareness,hope level and coping style of amputees with diabetes foot gangrene to a certain extent,and then improve the quality of life.