Objective:To investigate the expressions and clinical significance of E-cadherin and cyclin D1 in cutaneous squa-mous cell carcinoma(SCC)and basal cell carcinoma(BCC).Methods:The specimens of 96 patients with BCC were collected as BCC group,and the specimens of 80 patients with SCC were collected as SCC group.All specimens were clearly diagnosed.Im-munohistochemistry was used to detect the expression levels of E-cadherin and cyclin D1 in the specimens,and an analysis of correlation with clinicopathological characteristics was conducted by Spearman correlation analysis.Kaplan-Meier analysis was used to evaluate the relationship with survival prognosis.Results:In BCC and SCC groups,the positive expression rates of E-cadherin were 58.33％and 42.50％,and the positive expression rates of cyclin D1 were 30.21％and 60.00％,respectively(P＜0.05).A positive correlation was observed between positive state of E-cadherin and differentiation degree(P＜0.05),and showed a negative correlation with TNM staging as well as lymph node metastasis(P＜0.05),but Cyclin D1 revealed the op-posite correlation(P＜0.05).After 1 year of follow-up,patients with positive E-cadherin expression had longer progression-free survival time compared to those with negative expression(P＜0.05).Patients with positive cyclin D1 had shorter progres-sion-free survival time than those with negative expression(P＜0.05).There was no difference in survival time between stage I-Ⅱ patients with negative and positive E-cadherin(P＞0.05),and the survival time in stage Ⅲ patients with positive expres-sion was longer than that in patients with negative expression(P＜0.05).The survival time in stage I-Ⅱ patients with positive expression of cyclin D1 was shorter than that in patients with negative expression(P＜0.05),but there was no difference in stage Ⅲ patients(P＞0.05).Conclusion:The expressions of E-cadherin and cyclin D1 in BCC and SCC are different,and are closely related to clinicopathological characteristics,suggesting that the high expression of E-cadherin and low expression of cyc-lin D1 indicate a relatively good prognosis in BCC/SCC patients,which can be used as indicators for prognosis judgement.