Objective:To investigate the correlation between renal function indicators and the occurrence of cerebrovascular diseases in patients with renal failure.Methods:A total of 132 patients with renal failure were included in the study,and were di-vided into two groups based on the occurrence of cerebrovascular diseases:the cerebrovascular event group(n=26)and the non-cerebrovascular event group(n=106).The general data and various renal function indicators[serum creatinine(Cr),blood urea nitrogen(BUN),uric acid(UA),cystatin C(Cys-C),β2-microglobulin(β2-MG),urine albumin-to-creatinine ratio(ACR),and estimated glomerular filtration rate(eGFR)]were compared between the two groups.Multivariate Logistic regres-sion analysis was used to identify the risk factors for cerebrovascular disease in patients with renal failure.Spearman's method was employed for correlation analysis,and receiver operating characteristic(ROC)curve analysis was performed to evaluate the predictive value of each indicator for the occurrence of cerebrovascular diseases.Results:The levels of Cr,Cys-C,β2-MG,and ACR in the cerebrovascular event group were higher than those in the non-cerebrovascular event group(P＜0.05),while eGFR was lower in the cerebrovascular event group(P＜0.05).Regression analysis showed that Cr(OR=1.148),β2-MG(OR=2.073),and ACR(OR=1.018)were identified as independent risk factors for cerebrovascular events(P＜0.05).Correlation analysis showed that the levels of Cr,Cys-C,β2-MG,and ACR were positively correlated with the occurrence of cerebrovascular diseases,while eGFR was negatively correlated with cerebrovascular diseases(P＜0.05).The ROC curve analysis showed that the combined prediction model using Cr,β2-MG,and ACR had an area under the curve(AUC)of 0.955(95％CI:0.915～0.994),with a sensitivity of 96.2％and specificity of 80.8％.Conclusion:Cr,Cys-C,β2-MG,ACR,and eGFR are correlated with the occurrence of cerebrovascular diseases in patients with renal failure.Elevated Cr,β2-MG,and ACR are independent risk factors for cerebrovascular diseases.The combined use of Cr,β2-MG,and ACR offers a good predictive value for cerebrovascular diseases.