Objective:To analyze the influencing factors of neonatal lactose intolerance,develop a risk prediction model,and validate its predictive performance.Methods:A total of 307 neonates were selected as study subjects.Based on urine galactose test results and clinical manifestations,they were categorized into two groups:a lactose intolerance group(n=59)and a lactose tolerance group(n=248).By comparing the clinical data between the two groups,influencing factors were screened out using multivariate Logistic regression,and a risk prediction nomogram model was subsequently established.The predictive perform-ance of the model was assessed using the ROC curve,calibration curve,and clinical decision curve.Results:The incidence of lac-tase deficiency in newborns was 64.1％(198/307),the incidence of lactose intolerance was 19.22％(59/307),among newborns with lactase deficiency,the incidence of lactose intolerance was 29.8％(59/198).Gestational age serves as a protective factor a-gainst lactose intolerance in newborns,while a family history,prematurity,formula feeding,intestinal infection,antibiotic use,and malnutrition were risk factors for lactose intolerance in newborns(P＜0.05).The ROC curve of the prediction model re-vealed an AUC of 0.924,with a sensitivity of 0.770,a specificity of 0.949,and an optimal Youden index of 0.132.The Hosmer-Lemeshow test showed x2=9.671,with P＞0.05.Conclusion:Multiple high-risk factors contribute to neonatal lactose intoler-ance,and risk prediction models built upon these factors demonstrate good predictive efficacy.It is recommended that clinical in-terventions be implemented promptly and appropriately based on these influencing factors,in order to ameliorate the condition of lactose intolerance.