Objective:To analyze the application and prognosis of brain tissue oxygenation(PbtO2)combined with in-tracranial pressure(ICP)monitoring in treat-to-target for acute severe traumatic brain injury(sTBI)with multiple injuries.Methods:A total of 78 patients with sTBI and multiple injuries were selected.They were divided into the control group(receiv-ing ICP monitoring,n=39)and the observation group(receiving ICP combined with PbtO2 monitoring,n=39)according to different treatment methods.The brain-related parameters were compared between the two groups,and the prognosis was eval-uated.Results:The average ICP within 7 days,proportion of patients with intracranial hypertension,and total dosage of mannitol in the observation group were lower than those in the control group,while the average cerebral perfusion pressure was higher than that in the control group(P＜0.05).The proportion of patients with good prognosis and 6-month accumulative survival rate in the observation group were higher than those in the control group(P＜0.05).The average PbtO2 was positively correla-ted with glasgow outcome score in the observation group(P＜0.05).Conclusion:PbtO2 combined with ICP monitoring is of high value in the treatment of sTBI with multiple injuries.It can well reflect the status of cerebral hypoxia and ischemia in pa-tients and improve the short-term prognosis.