Objective:To investigate the effects of oxybuprocaine hydrochloride gel combined with propacetamol on cardio-vascular stress,anaesthesia and haemodynamics in patients undergoing laparoscopic cholecystocholedochotomy.Methods:80 pa-tients undergoing elective laparoscopic cholecystocholangiography were selected as study subjects and divided into a control group and a combined group based on different anesthesia protocols used during the operation,with 40 cases in each group.The control group received propacetamol intravenous injection,and the combined group received topical anesthesia with oxybupro-caine hydrochloride gel in addition to the treatment given to the control group.The operation time,anesthesia time,recovery time,extubation time,blood oxygen saturation(SaO2),heart rate(HR),mean arterial pressure(MAP),catecholamines,corti-sol,blood glucose,pain[Visual Analog Scale(VAS)],and the incidence of adverse reactions were recorded and compared be-tween the two groups.Results:There were no significant differences in operation time,anesthesia time,emergence time,and ex-tubation time between the two groups of patients(P>0.05).At 15 and 30 min post-extubation,both HR and MAP were lower in the combination group compared to the control group(P<0.05).On postoperative day 1,catecholamines,cortisol,and blood glucose levels were elevated in both groups,but the levels were lower in the combination group compared to the control group(P<0.05).VAS scores were lower in the combination group compared to the control group immediately after extubation,and at 15 min and 30 min post-extubation(P<0.05).The incidence of adverse reactions was lower in the combination group com-pared to the control group(P<0.05).Conclusion:In laparoscopic cholecystobiliary choledochotomy,compared with propaceta-mol anaesthesia alone,combined with oxybuprocaine hydrochloride gel anaesthesia is more conducive to reducing the degree of postoperative pain and haemodynamic fluctuations of the patient,and can effectively inhibit the patient's level of postoperative cardiovascular stress response,which can help to increase the degree of patient's tolerance to catheterisation.