Objective:To explore the correlation between the naples prognostic score(NPS)and the clinicopathological characteristics and prognosis of patients with newly diagnosed Colorectal Cancer(CRC).Methods:The clinicopathological char-acteristics and prognosis data of 188 diagnosed CRC patients were collected.The cumulative NPS score was calculated based on the pre-treatment serum ALB(<4 g/dL:1 point,≥4 g/dL:0 point),TC(≤180 mg/dL:1 point,>180 mg/dL:0 point),NLR(>2.96:1 point,≤2.96:0 point),and LMR(≤4.44:1 point,>4.44:0 point).The patients were divided into Group A(0 points),Group B(1～2 points),and Group C(3～4 points),and the differences in clinicopathological characteristics and prognosis among the three groups were analyzed.Results:There were statistically significant differences in age,maximum tumor diameter,neurovascular invasion,perivascular invasion,liver metastasis,CA-125,TNM stage,and post-treatment compli-cations among the NPS groups(P<0.05).Univariate Cox analysis showed that NPS was significantly associated with OS(HR=2.477,95%CI:1.468～4.181,P=0.001).After controlling for confounding factors,multivariate analysis showed that NPS remained an independent prognostic factor(HR=2.359,95%CI:1.368～4.067,P=0.002).The K-M curve based on 3-year OS indicated that the prognosis of the high NPS group(Group C)was worse.The ROC curve showed that NPS(AUC=0.691)had better predictive efficacy compared with PNI,SIS,NLR,and LMR,and the NPS+TNM combined model(AUC=0.833)was superior to the single TNM staging(AUC=0.792),It had a good calibration ability.Conclusion:NPS can identify newly diagnosed CRC patients with high inflammatory load and poor nutritional status.It is an independent risk factor for poor prognosis.Its predictive efficacy is higher than that of the classic predictive scores PNI,SIS,NLR,and LMR.When used in combination with TNM,it can further optimize stratified management and provide certain value for clinical diagnosis and treat-ment before treatment.