Objective:To compare the clinical efficacy of copper-nickel-titanium(Cu-Ni-Ti)and conventional nickel-titani-um(Ni-Ti)archwires during orthodontic alignment.Methods:72 first-time orthodontic patients were selected as the research subjects and divided into a study group(Cu-Ni-Ti)and a control group(Ni-Ti)according to different treatment materials.In-tercanine/intermolar widths,maxillary Little's Irregularity Index(LII),and VAS pain scores(24 h post-activation)were recor-ded at baseline(T0),3 months(T1),and finishing archwire stage(T2).Treatment duration and unscheduled visits were ana-lyzed.Results:There were no statistically significant differences in treatment duration or improvement in dental arch morpholog-ical parameters between the two groups(P>0.05).Patients in the study group demonstrated lower initial 24-hour VAS pain scores and required fewer clinical appointments compared to the control group(P<0.05).However,intergroup differences in pain scores at both T1 and T2 stages showed no statistical significance(P>0.05).Conclusion:Cu-Ni-Ti have shown advantages in reducing initial pain and fewer clinical appointments,and can be used as one of the options for initial archwires during ortho-dontic alignment.