Objective: To analyze the application value of the Conceive–Design–Implement–Operate (CDIO) nursing mode in patients undergoing endoscopic surgery for chronic rhinosinusitis (CRS). Methods: A total of 186 patients who underwent surgery for CRS were selected as research subjects. According to different nursing methods, they were divided into the control group and the CDIO group, with 93 cases in each group. The control group received routine nursing care, while the CDIO group received nursing intervention based on the CDIO model. All patients received the assigned interventions until discharge. Pain intensity [Visual Analog Scale (VAS)], psychological status [Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS)], quality of life [Sino-Nasal Outcome Test-20 (SNOT-20)], and postoperative complication rates were compared between the two groups. Results: Compared to the control group, the CDIO group had significantly lower VAS scores at 6 and 12 hours postoperatively, and lower SAS, SDS, and SNOT-20 scores at discharge (P < 0.05). The postoperative complication rate was also significantly lower in the CDIO group (P < 0.05). Conclusion: The CDIO nursing intervention model can effectively reduce postoperative pain and complication rates, and improve psychological well-being and quality of life in patients with chronic rhinosinusitis undergoing endoscopic sinus surgery.