Objective: To investigate the effects of different nerve block techniques on postoperative pain control and functional recovery in patients following anterior cruciate ligament reconstruction (ACLR). Methods: 153 patients scheduled for unilateral arthroscopic ACLR were selected. According to the different intervention methods, they were divided into group A (sciatic-femoral nerve block), group B (sciatic-adductor canal block), and group C (sciatic-femoral-obturator nerve block), with 51 cases in each group. The Visual Analog Scale (VAS) scores, quadriceps femoris muscle strength, joint function, and adverse reactions were compared among the groups. Results: At 4, 8, and 12 h postoperatively, VAS scores in resting state and during passive movement in group C were all lower than those in group A and group B (P<0.05), and the quadriceps femoris muscle strength of group B was greater than that of group A and group C (P<0.05). At 72 h postoperatively, the Hospital for Special Surgery (HSS) knee score in group B was higher than that in group A and that in group C. The time to active straight leg raising and passive knee flexion to 90° was shorter than group A and group C (P<0.05). There was no statistically significant difference in the incidence of adverse reactions among the three groups (P>0.05). Conclusion: Adopting sciatic-femoral-obturator nerve block in arthroscopic ACLR can achieve good early analgesic effect, while sciatic+adductor canal block is more conducive to muscle strength and joint function re