Objective: To explore the relationship between neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), lymphocyte/monocyte ratio (LMR) and injury in foveal avascular zone (FAZ), prognosis of patients with diabetic retinopathy (DR). Methods: A total of 123 patients with DR were enrolled, and all underwent optical coherence tomography angiography (OCTA). According to presence or absence of FAZ contour injury, patients were divided into injury group (n=60) and non-injury group (n=63), NLR, PLR and LMR levels in the two groups were compared. The relationship between FAZ contour injury and NLR, PLR, LMR were analyzed by Spearman correlation analysis. Taking whether there was visual disability after 1 year of follow-up as prognosis evaluation criteria, patients were divided into visual improvement group (n=86) and visual disability group (n=37), NLR, PLR and LMR levels in the two groups were compared. The predictive value of NLR, PLR and LMR levels for prognosis of DR was analyzed by ROC curves. Results: NLR and PLR in injury group were higher than those in non-injury group (P<0.05), while LMR was lower than that in non-injury group (P<0.05). NLR and PLR were positively correlated with FAZ contour injury (P<0.05), while LMR was negatively correlated with FAZ contour injury (P<0.05). NLR and PLR in visual disability group were higher than those in visual improvement group (P<0.05), while LMR was lower than that in visual improvement group (P<0.05). ROC curve analysis showed that area under the curve (AUC) values of NLR, PLR, LMR and combined detection for predicting prognosis of DR were 0.799, 0.807, 0.812 and 0.959, and their cut-off values were 2.82, 139.47 and 3.71, respectively. Conclusion: The levels of NLR, PLR and LMR are all related to FAZ contour injury in DR patients, which can also be applied as auxiliary detection indexes to clinically predict visual prognosis in DR patients.