Objective: Based on the method of bibliometrics, this paper systematically sorts out the characteristics, core research strength, influence of highly cited literature, research hotspots and evolution trends of sericin protein, objectively presents the knowledge structure and development context of this field, and provides data support and reference for subsequent research topics, direction innovation and optimal allocation of resources. Methods: The core collection of Web of Science was used as the data source, and the search terms sericin, silk sericin, sericin protein were set. The academic literature related to sericin protein from 2015 to 2025 was retrieved (limited to Article, Review). After duplicate checking and screening by Note Express, Excel, CiteSpace, VOSviewer and other tools were used to conduct statistical and visual analysis from the dimensions of annual publication volume, country distribution, research institutions and keywords. Results: A total of 1,713 eligible literatures were included. The annual number of publications showed a steady growth trend, China was the core publishing country, Huazhong University of Science and Technology, Southwest University and others were the core research institutions. Keyword analysis showed that the research hotspots focused on the material properties, biological activity and application direction of sericin protein. The emergence of keywords indicates that antibacterial, sericin hydrogel and cell viability were the research frontiers after 2023. Conclusion: The research heat in the field of sericin protein continues to rise, and has formed a research pattern led by China and supported by core institutions and teams. The core research focuses on biomedical applications. At present, there were some problems in the research, such as insufficient depth of cross-regional cooperation and weak connection of clinical transformation. In the future, the development of multifunctional composite materials, optimization of standardized extraction process and clinical transformation research should be strengthened to promote the practical and accurate development of the field.