Abstract:Objective:To explore the mechanism of circ_0014130/miR-671-5p/PDL1 axis in the progression of gastric cancer.Methods:In order to explore the role of circ_0014130 and miR-671-5p in gastric cancer cells,AGS and HGC27 cells were divided into si-NC group,si-circ_0014130 group,si-circ_0014130+inhibitor NC group and si-circ_0014130+miR-671-5p inhibitor group.In order to explore the role of miR-671-5p and PDL1 in gastric cancer cells,AGS and HGC27 cells were divided into mimic NC group,miR-671-5p mimic group,miR-671-5p mimic+pcDNA-NC group,and miR-671-5p mimic+pcDNA-PDL1 group.The targeting binding relation-ship between circ_0014130 and miR-671-5p,miR-671-5p and PDL1 were analyzed by Dual luciferase reporter gene assay.The cell via-bility was detected by CCK-8 assay,cell proliferation was detected by EdU assay,cell apoptosis was detected by flow cytometry,and cell invasion was detected by Transwell assay.The RNA expression level was detected by RT-qPCR,and protein expression level of PCNA,Bcl-2,Bax and PDL1 were detected by western blot.Results:There was a binding site between circ_0014130 and miR-671-5p,and the expression of circ_0014130 was increased in AGS and HGC27 cells(P＜0.05).The knockdown of circ_0014130 expression inhibited cell proliferation and invasion,promoted cell apoptosis.The down-regulation of miR-671-5p counteracted the inhibitory effect of circ_0014130 knockout on the malignant biological behavior of gastric cancer cells.There was a binding site between miR-671-5p and PDL1,and overexpression of miR-671-5p inhibited cell proliferation and invasion,promoted cell apoptosis.The overexpression of PDL1 partially offset the inhibitory effect of miR-671-5p on the malignant biological behavior of gastric cancer cells.Conclusion:circ_0014130 may promote the proliferation and invasion of gastric cancer cells and inhibit the apoptosis of gastric cancer cells by regulating miR-671-5p/PDL1 axis.

Abstract:Objective:To explore the molecular mechanism of resveratrol(RSV)in the treatment of oral squamous cell carcino-ma(OSCC)based on the combination of transcriptome and proteome.Methods:Oral squamous cell carcinoma HSC-3 cells were cul-tured in vitro and divided into the control group and RSV group.Combined transcriptome and proteome analysis was performed in con-trol group and RSV group to screen key targets and related signaling pathways for intervention in OSCC.The cells were divided into blank control group,RSV 50 μmol/L group,and RSV 100 μmol/L group,mRNA expression levels of core differential genes/proteins,namely neural cadherin(N-cadherin),Vimentin,epithelial cadherin(E-cadherin)and matrix metalloproteinase-9(MMP9)were detec-ted by RT-qPCR and Western blot.Results:After RSV treatment of HSC-3 cells,transcriptome analysis showed that there were 422 dif-ferentially expressed genes in RSV group,of which 276 were up-regulated and 146 were down-regulated.Differentially expressed genes were mainly concentrated in epithelial mesenchymal transformation(EMT)signaling pathway.Proteomic analysis showed that there were 644 differentially expressed proteins in RSV group,of which 342 were up-regulated and 302 were down-regulated.By combining transcriptome-proteome comparisons,117 intersection targets were identified,including E-cadherin,N-cadherin,MMP9 and Vimentin in EMT signaling pathways.The results of RT-qPCR showed that RSV up-regulated the expression of E-cadherin mRNA and down-regula-ted the expression of N-cadherin,Vimentin and MMP9 mRNA,which was consistent with the transcriptomic results.Western blot experi-ment results showed that RSV treatment increased the protein expression level of E-cadherin and decreased the protein expression level of N-cadherin,Vimentin and MMP9,which was positively correlated with RSV concentration and consistent with proteomic results.Con-clusion:RSV inhibits the metastasis of oral squamous cell by regulating the expression of EMT signaling pathway molecules E-cadherin,N-cadherin,MMP9 and Vimentin in HSC-3 cells.

Abstract:Objective:To investigate the effect and mechanism of daphnetin-induced autophagy in human glioblastoma U-251 cells.Methods:After U-251 cells were treated with different concentrations of daphnetin for 48 h,the number and formation of autopha-gosomes in U-251 cells were observed by transmission electron microscopy.Western blot was used to detect the expression of autophagy-related proteins mTOR,P62,Beclin-1 and LC-3.Results:Compared with the control group,the number of autophagosomes in U-251 cells was increased after treatment with 40,80 and 160 μg/mL daphnetin for 48 h.The expression levels of mTOR,Beclin-1 and LC-3 proteins were increased,while the expression level of P62 protein was decreased in a dose-dependent manner.Conclusion:Daphnetin may promote autophagy in U251 cells by up-regulating the expression of mTOR,Beclin-1 and LC-3 proteins and down-regulating the ex-pression of P62 protein.

Abstract:Objective:To explore the application effects of tendon incision localization(TI)and anterior medial localization(AM)in anterior cruciate ligament(ACL)reconstruction.Methods:According to different femoral tunnel localization methods,129 patients who underwent elective arthroscopic ACL reconstruction were divided into TI group(tendon incision positioning,n=65)and AM group(anterior medial positioning,n=64).The general surgical condition,angle and length of femoral tunnel,knee function before surgery,1 month and 3 months after surgery,and surgical complications in 3 months after surgery were compared between the two groups.Results:There was no significant difference between the two groups in terms of diameter of the graft,length of hospital stay,the length of femoral tunnel,and the incidence of surgical complications(P＞0.05).The time for tendon retrieval and surgery time in TI group was shorter than that in AM group(P＜0.05).Sagittal and coronal angles were larger than those in AM group(P＜0.05).Com-pared with preoperative scores,Lysholm scores of both groups increased 1 month and 3 months after surgery(P＜0.05).However,there was no significant difference between the groups(P＞0.05).Conclusion:Applying TI localization can shorten the time for tendon re-trieval and surgery time,and obtain a larger femoral tunnel angle.Both localization techniques can achieve satisfactory clinical results within 3 months after surgery,and the incidence rates of surgical complications are comparable.

Abstract:Objective:To investigate the effects of rosuvastatin combined with metoprolol succinate on apolipoproteins,non-high-density lipoprotein cholesterol(non-HDL-C)/high-density lipoprotein cholesterol(HDL-C)ratio,and liver function in patients with at-rial fibrillation.Methods:102 patients with atrial fibrillation were divided into a control group and a combination group based on differ-ent treatment regimens,with 51 cases in each group.The control group was treated with metoprolol succinate,while the combination group received rosuvastatin in addition to the treatment given to the control group.Both groups were treated continuously for 6 months.Blood lipids,inflammation markers,liver function,atrial fibrillation episodes,cardiac function,treatment efficacy,and adverse reactions were recorded and compared between the two groups.Results:After treatment,the levels of apolipoprotein A(ApoA)and non-HDL-C/HDL-C in the combination group were lower than those in the control group,while the level of apolipoprotein B(ApoB)was higher in the combination group(P＜0.05).The levels of high-sensitivity C-reactive protein(hs-CRP)and interleukin-6(IL-6)in the combi-nation group were also lower than those in the control group(P＜0.05).There was no significant difference in alanine aminotransferase(ALT)and aspartate aminotransferase(AST)levels between the two groups(P＞0.05).After treatment,the duration and frequency of atrial fibrillation episodes in the combination group were lower than those in the control group(P＜0.05),the left atrial volume(LAV)in the combination group was lower,and the left atrial ejection fraction(LAEF)was higher than in the control group(P＜0.05),the effective treatment rate in the combination group was higher than in the control group(P＜0.05).The incidence of adverse reactions was not significantly different between the two groups(P＞0.05).Conclusion:The treatment with rosuvastatin combined with metopro-lol succinate is beneficial in reducing blood lipids and inflammation levels in patients with atrial fibrillation,improving cardiac function,demonstrating significant treatment efficacy,and showing good clinical outcomes.

Abstract:Objective:To explore the effects of different fixation methods on the short-and long-term lower limb function in pa-tients with trimalleolar fractures.Methods:A retrospective analysis was conducted on clinical data from 84 patients with trimalleolar fractures patients were divided into two groups based on their posterior malleolus fracture fixation method:a plate fixation group(n=45)and a cannulated screw fixation group(n=39).Surgical indicators(operation time,intraoperative blood loss,postoperative hospital stay),preoperative and early postoperative ankle plantarflexion and dorsiflexion angles,Visual Analogue Scale(VAS)pain scores,and American Orthopaedic Foot & Ankle Society(AOFAS)Ankle-Hindfoot Scores were compared between the two groups.All patients un-derwent follow-up for 12 months after surgery to compare the time to posterior malleolus union and AOFAS Ankle-Hindfoot Scores at 6 and 12 months postoperatively.Results:The operation time was longer in the plate fixation group compared to the cannulated screw fixa-tion group(P＜0.05).There were no significant differences between the two groups in terms of intraoperative blood loss and postopera-tive hospital stay(P＞0.05).1 month postoperatively,both groups showed increased ankle plantarflexion and dorsiflexion angles,with the plate fixation group having larger angles than the cannulated screw fixation group(P＜0.05).At 1 month postoperatively,both groups had reduced pain Visual Analogue Scale(VAS)scores and increased American Orthopaedic Foot & Ankle Society(AOFAS)Ankle-Hindfoot Scores(P＜0.05),with the plate fixation group showing greater changes in both VAS scores and AOFAS Ankle-Hind-foot Scores compared to the cannulated screw fixation group(P＜0.05).There was no significant difference in the short-term treatment success rate between the two groups(P＞0.05).The time to posterior malleolus union and AOFAS Ankle-Hindfoot Scores at 6 and 12 months postoperatively did not differ significantly between the plate fixation group and the cannulated screw fixation group(P＞0.05).Conclusion:Compared to cannulated screw fixation,plate fixation is more beneficial for early postoperative recovery of ankle function in patients with trimalleolar fractures.However,there are no significant differences between the two fixation methods in terms of long-term lower limb function.

Abstract:Objective:To investigate the clinical characteristics and risk factors of neonatal hyperthyrotropinemia(HT).Meth-ods:The clinical data of 872 neonates were retrospectively analyzed.According to the age of birth,they were divided into preterm group and full-term group.Serum thyroid stimulating hormone(TSH)level,prevalence rate of HT and clinical characteristics were compared between groups.Logistic binary regression equation was used to analyze the risk factors of neonatal HT.Results:Among the 872 neo-nates,there were 105 cases of preterm infants and 767 cases of full-term infants,and 216 cases were with HT,accounting for 24.77％.The prevalence rate of HT in preterm group and full-term group was 37.14％and 23.08％,the prevalence rate of HT and serum TSH level in preterm group were higher than those in full-term group(P＜0.05).The proportions of low birth weight,intrauterine distress,elderly parturient women,history of adverse pregnancy and thyroid dysfunction during pregnancy in HT children in preterm group and full-term group were higher than those in non-HT children(P＜0.05),and the birth head circumference and body length were lower than those in non-HT children(P＜0.05).Logistic regression equation analysis showed that preterm delivery,low birth quality,intrau-terine distress,elderly parturient women,adverse pregnancy history,and thyroid dysfunction during pregnancy were all risk factors for neonatal HT(P＜0.05).Conclusion:Preterm birth,low birth weight,intrauterine distress,elderly parturient women,adverse pregnancy history,and thyroid dysfunction during pregnancy are all risk factors for neonatal HT.It is necessary to enhance clinical attention and actively take preventive measures.

Abstract:Objective:To investigate the impact of combining selective serotonin reuptake inhibitors(SSRIs)with occupational therapy(OT)on neurological functioning,psychological well-being,and activities of daily living in individuals diagnosed with post-stroke depression(PSD).Methods:A total of 90 patients diagnosed with post-stroke depression were selected as the research subjects.They were divided into two groups according to different treatment methods,namely the control group(n=45)and the experimental group(n=45).The control group received treatment with SSRIs,while the experimental group received a combination of SSRIs and OT.The overall treatment efficacy,levels of norepinephrine(NE),5-hydroxytryptamine(5-HT),brain-derived neurotrophic factor(BDNF),insulin-like growth factor-1(IGF-1),Hamilton depression scale(HAMD)score,activities of daily living(ADL)score,and Pittsburgh sleep quality Index(PSQ)were compared between the two groups before and after treatment,including the incidence of ad-verse reactions.Results:The total effective rates of the the experimental group was higher than that of the control group(95.56％vs.80.00％,P＜0.05).After treatment,the serum levels of NE,IGF-1,5-HT,and BDNF in both groups exhibited improvement compared to pre-treatment levels(P＜0.05).Furthermore,the experimental group demonstrated superior post-treatment serum levels of NE,IGF-1,5-HT,and BDNF when compared to the control group(P＜0.05).After treatment,the ADL scores of both groups exhibited a signifi-cant improvement compared to pre-treatment levels(P＜0.05),the PSQI scores of both groups demonstrated a decrease in comparison to pre-treatment values(P＜0.05).Moreover,the experimental group displayed superior post-treatment ADL and PSQI scores when compared to the control group(P＜0.05).The incidence of adverse reactions in the two groups was 2.22％and 17.78％,respective-ly,with a lower rate observed in the experimental group compared to the control group(P＜0.05).Conclusion:The use of SSRIs com-bined with OT treatment in PSD patients can enhance psychological well-being,improve sleep quality,regulate neurotransmitter levels,thereby enhancing daily functioning and increasing the safety profile of the treatment.This approach offers significant advantages.

Abstract:Objective:To explore the predictive value of combined detection of peripheral blood chemokine ligand-18(CCL18),soluble triggering receptor expressed on myeloid cells-1(sTREM-1)and high-sensitivity C-reactive protein/albumin(hs-CRP/Alb)on the prognosis of patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods:The data of 286 pa-tients with AECOPD were retrospectively analyzed and the patients were enrolled as study group,they were classified into grade Ⅰ(n=91),Ⅱ(n=122),and Ⅲ(n=73)groups by disease severity,and divided into poor prognosis group(n=63)and good prognosis group(n=223)according to the prognosis,and 200 healthy subjects with physical examination were selected as control group.The lev-els of CCL18,sTREM-1 and hs-CRP/Alb in peripheral blood were compared between the two groups.The levels of peripheral blood CCL18,sTREM-1 and hs-CRP/Alb were compared among patients with different disease severities.To analyze the correlation between levels of peripheral blood CCL18,sTREM-1 and hs-CRP/Alb and disease condition.To analyze the predictive value of peripheral blood CCL18,sTREM-1 and hs-CRP/Alb levels on the prognosis of AECOPD patients.Results:The levels of peripheral blood CCL18,sTREM-1 and hs-CRP/Alb in study group were higher than those in control group(P＜0.05).The levels of CCL18,sTREM-1 and hs-CRP/Alb in peripheral blood of patients with AECOPD grade Ⅰ were lower than those of patients with grade Ⅱ or Ⅲ AECOPD(P＜0.05),and the above levels of patients with AECOPD grade Ⅱ were lower than those of patients with AECOPD grade Ⅲ patients(P＜0.05).The levels of CCL18,sTREM-1 and hs-CRP/Alb in peripheral blood were higher in poor prognosis group than those in good prognosis group(P＜0.05).Spearman correlation coefficient analysis showed that the levels of peripheral blood CCL18,sTREM-1 and hs-CRP/Alb were positively correlated with disease condition of AECOPD patients(P＜0.05).Receiver operating characteristic curve curve analysis suggested that the sensitivities of CCL18,sTREM-1,hs-CRP/Alb alone and in combination in predicting the prog-nosis of AECOPD patients were 71.43％,71.43％,76.19％and 84.13％respectively,and the specificities were 70.40％,72.20％,73.99％and 68.16％,and the AUCs were 0.791,0.777,0.821 and 0.935 respectively.The combined diagnostic value was higher(P＜0.05).Conclusion:The levels of serum CCL18,sTREM-1 and hs-CRP/Alb in patients with AECOPD are up-regulated,and are correlated with disease condition,and they can be used for prognosis evaluation.

Abstract:Objective:To explore the risk factors of acute traumatic coagulopathy(ATC)in patients with severe trauma,and construct its nomogram prediction model.Methods:178 patients with severe trauma were selected as the research subjects.They were divided into ATC group(n=60)and non-ATC group(n=118)according to whether ATC occurred.The clinical data of patients were collected,and the independent risk factors of ATC in patients with severe trauma were established by univariate and Logistic multivariate regression analysis.R software was used to construct a nomogram prediction model for ATC in patients with severe trauma by incorpora-ting the screened independent risk factors,and the receiver operating characteristic(ROC)curve was drawn to verify the predictive effi-cacy of the model.Results:Of the 178 patients with severe trauma,60 had ATC,with an incidence of 33.71％(60/178).Univariate analysis showed that the blood transfusion and blood product use in ATC group were higher than those in non-ATC group(P＜0.05).APTT,TT,INR,BUN,lactic acid,BE,and SI in ATC group were higher than those in non-ATC group(P＜0.05),FIB and PLT were lower than those in non-ATC group(P＜0.05).Multivariate Logistic regression analysis showed that low FIB(OR=0.557),low PLT(OR=0.692),high lactic acid(OR=1.241),and high SI(OR=1.533)were independent risk factors for ATC in patients with se-vere trauma(P＜0.05).The ROC curve showed that the area under the curve(AUC)of the nomogram prediction model was 0.895(95％CI=0.840～0.936),and the sensitivity and specificity were 85.00％and 83.90％,respectively.Conclusion:Low FIB,low PLT,high lactic acid,and high SI are independent risk factors for ATC in patients with severe trauma.The nomogram prediction model constructed on this basis can better predict the probability of ATC in patients.

Abstract:Objective:To investigate and compare the diagnostic value of dynamic contrast-enhanced MRI(DCE-MRI)and musculoskeletal ultrasound(MSUS)for the activity of rheumatoid arthritis(RA).Methods:The clinical data of 97 patients with RA who received DCE-MRI and MSUS in the hospital were retrospectively analyzed.The detection rates of typical pathological features of RA patients by DCE-MRI and MSUS at admission were compared.The patients were divided into an active group(DAS28 ≥2.6 points,n=56)and an inactive group(DAS28＜2.6 points,n=41)according to the disease activity[rheumatoid arthritis disease activity sco-ring system(DAS28)score].The quantitative parameters of DCE-MRI[early enhancement rate(EER),maximum enhancement rate(MER),time to peak(TTP)]and MSUS[synovial thickness,blood flow signal score,synovial artery resistance index(RI)]of pa-tients with different disease activities were compared at admission.The diagnostic efficiency of quantitative parameters of these two ima-ging techniques for the disease activity of RA patients was analyzed by receiver operating characteristic curve(ROC).Results:There was no statistical significance in the detection rate of synovial hyperplasia in RA patients between the two imaging techniques(P＞0.05).The detection rate of bone erosion in RA patients by DCE-MRI was higher than that by MSUS while the detection rate of joint ef-fusion was lower than that by MSUS(P＜0.05).At admission,the EER,MER,synovial thickness and blood flow signal score in active group were higher while the TTP and synovial artery RI were lower than those in inactive group(P＜0.05).ROC analysis showed that the areas under the ROC curves(AUCs)for EER,MER,TTP,synovial thickness,blood flow signal score and synovial artery RI were 0.788,0.846,0.806,0.865,0.626 and 0.819,the sensitivities were 75.61％,92.68％,70.73％,78.05％,87.80％and 75.61％,and the specificities were 71.43％,64.29％,76.79％,78.57％,32.14％and 82.14％,respectively(P＜0.05).Conclusion:Both DCE-MRI and MSUS have good diagnostic value on RA activity,but DCE-MRI has a higher detection rate of bone erosion in RA pa-tients,while MSUS has a higher detection rate of joint effusion.

Abstract:Objective:To investigate the effect of pulmonary ultrasound B-line score on the guidance and prognosis of early fluid resuscitation in patients with severe acute pancreatitis(SAP).Methods:90 patients with SAP were divided into control group(n=45)and observation group(n=45)according to the different ways of fluid management.Both groups received positive fluid therapy guided by the EGDT strategy.The control group used increased lung rales and oxygen desaturation as a sign of reverse fluid resuscitation,while the observation group used lung ultrasound B-line score to guide fluid management.The total liquid balance was compared between the two groups at the initial 6 h,1 d,2 d and 48 h.The tissue perfusion and oxygen metabolism indexes[oxygenation index(PaO2/FiO2),blood lactate and central venous oxygen saturation(ScvO2)]were compared between the two groups at 0,6,12 and 24 h.The levels of B-type natriuretic peptide(BNP)and intra-abdominal pressure(IAP)were compared between the two groups at the time of enroll-ment,24 and 48 h after treatment,and the endpoint events[6 h resuscitation compliance rate,incidence of multiple organ dysfunction syndrome(MODS)and mortality]were compared between the two groups.Results:The total amount of fluid balance in the observation group was less than that in the control group at the initial 6 h,1 d,2 d and the first 48 h(P＜0.05).The PaO2/FiO2 and blood lactate in the two groups decreased with time,and PaO2/FiO2 in the observation group was higher at each time point after resuscitation(P＜0.05),blood lactate was lower(P＜0.05),the ScvO2 of the two groups increased with time,and the observation group was higher at 24 h of resuscitation(P＜0.05).BNP and IAP levels in both groups increased over time,and the observation group was lower at each time point after resuscitation(P＜0.05).The 6-hour resuscitation compliance rate in the observation group was higher than that in the con-trol group,and the incidence of MODS was lower than that in the control group(P＜0.05).There was no statistically significant differ-ence in the 28-day mortality rate between the observation group and the control group(P＞0.05).Conclusion:Pulmonary ultrasound B-line score has high clinical value in guiding early fluid resuscitation in SAP patients.1t is helpful to adjust the amount of fluid resusci-tation in time,effectively improve the levels of PaO2/FiO2 and ScvO2,reduce the level of blood lactate,improve the microcirculation of patients,reduce the risk of fluid overload,and improve the overall prognosis of patients.

Abstract:Objective:To explore the diagnostic efficacy and clinical value of the signal ratio of MRI conventional sequences and the apparent diffusion coefficient(ADC)value in multiple myeloma(MM).Methods:35 patients with newly diagnosed MM and 43 normal controls were recruited.Lumbar MRI conventional sequences(T1 WI,T2WI,SPAIR)and DWI scans were performed.The differ-ences in sequence signal ratios and ADC values between MM(including subgroups of MM at different stages)and the normal control group were compared.Sensitivity and specificity were analyzed using ROC curves.The ADC cutoff value was obtained.The differences in the area under the ROC curves were compared.Results:The T1 WI signal ratio of the MM group was lower than that of the normal control group(P＜0.01),with the sensitivity and specificity of 0.97 and 0.93 respectively.The SPAIR signal ratio was higher than that of the normal control group(P＜0.01),with the sensitivity and specificity of 0.68 and 0.97 respectively.The ADC value was higher than that of the normal control group(P＜0.05),with the sensitivity and specificity of 0.93 and 0.95 respectively.The ADC cutoff value was 0.52(×10-3mm2/s).The area under the ROC curve(AUC)was:ADC value＞T1WI signal ratio＞SPAIR signal ratio.Pairwise analysis of AUC showed that there was no statistically significant difference between the T1WI signal ratio and the ADC value(P＞0.05),and both had the same evaluation efficacy,which was superior to that of the SPAIR signal ratio,and the difference was statistically significant(P＜0.05).Conclusion:The T1 WI signal ratio and ADC value have high sensitivity and specificity,and their diagnostic efficacy is better than that of the SPAIR signal ratio.There is a significant difference when the ADC value is higher than 0.52.The combined application of T1WI and ADC value is conducive to the diagnosis of MM.

Abstract:Objective:To analyze the clinical efficacy of early application of Buyang Huanwu Decoction after Zero-P interverte-bral fusion fixation surgery in the treatment of cervical spondylotic radiculopathy.Methods:90 patients with cervical spondylotic radicu-lopathy who underwent the Zero-P procedure were divided into two groups based on treatment methods:the control group(underwent Zero-P surgery alone,n=45)and the treatment group(received Buyang Huanwu Decoction early after Zero-P surgery for one month,n=45).The visual analog scale(VAS),cervical dysfunction index(NDI),and traditional Chinese medicine syndrome score of pain were compared between two groups before surgery and at 1 w,1 m,and 3 m after surgery.The levels of tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β),and interleukin-6(IL-6)were measured and compared before surgery and at 1 w,1 m post-surgery.Re-sults:The VAS scores,NDI scores,and TCM syndrome scores of both groups at 1 w,1 m,and 3 m after surgery were lower than those before surgery(P＜0.05),and the degree of reduction increased over time(P＜0.05).The treatment group showed more significant reductions at corresponding time points compared to the control group(P＜0.05).Both groups showed decreases in TNF-α,IL-1β,and IL-6 levels at 1 w and 1 m after surgery compared to before surgery(P＜0.05),and the treatment group showed lower levels at corre-sponding time points compared to the control group(P＜0.05).Conclusion:Early application of Buyang Huanwu Decoction after Zero-P interbody fusion fixation can reduce inflammatory response,significantly improve pain,restore cervical function,and accelerate recov-ery in patients with cervical radiculopathy.

Abstract:Objective:To explore the effect of continuous blood purification(CBP)combined with levosimendan on the clinical efficacy and inflammatory factors in patients with severe pneumonia complicated with heart failure.Methods:86 patients with severe pneumonia and heart failure were selected and divided into two groups with 43 cases according to different treatment methods,the con-trol group was treated with levosimendan,while the observation group received CBP treatment on top of the treatment provided to the control group.The therapeutic effects,echocardiographic indicators[left ventricular ejection fraction(LVEF),mitral valve flow velocity(MV),cardiac output(CO)],inflammation markers[interleukin-6(IL-6),procalcitonin(PCT)],and acid-base balance indicators[pH value,bicarbonate(HCO3-),arterial oxygen tension(PaO2)]before and after treatment were compared between the two groups.Results:The treatment efficacy rate was higher in the observation group than in the control group(P＜0.05).After treatment,both groups showed increased LVEF,MV,and CO(P＜0.05),with the observation group exhibiting greater increases in LVEF and MV compared to the control group(P＜0.05),there was no significant difference in CO between the two groups(P＞0.05).Post-treatment levels of PCT and IL-6 decreased in both groups,with a more significant decrease observed in the observation group(P＜0.05).Addi-tionally,both pH values,and PaO2 increased while HCO3-level decreased,and the change were more significant in the observation group(P＜0.05).Conclusion:CBP combined with levosimendan can further improve cardiac function,reduce inflammatory responses,and better regulate acid-base balance in patients with severe pneumonia complicated by heart failure.

Abstract:Objective:To explore the efficacy of Guizhi Fuling capsule combined with dinogest(DNG)in the treatment of endo-metriosis(EMT)and influence on levels of platelet activating factor(PAF)and transforming growth factor-β1(TGF-β1)in patients with EMT.Methods:98 patients with EMT were retrospectively studied.According to different treatment methods,they were divided into DNG group(n=45,DNG treatment)and combined group(n=53,Guizhi Fuling capsule combined with DNG treatment).The clinical efficacy after 3 menstrual cycles of treatment and TCM syndromes scores,PAF and TGF-β1,hemorheology,hemodynamic indicators and visual analogue scale(VAS)score before and after treatment were compared between groups.Results:After treatment,the efficacy in combined group was better than that in DNG group(P＜0.05).The TCM syndromes scores,PAF,TGF-β1,plasma viscosity,hemato-crit,erythrocyte sedimentation rate and VAS score in the two groups were decreased compared to before treatment(P＜0.05),and the above indicators were lower in combined group(P＜0.05).The maximum blood flow velocity was increased in both groups compared with that before treatment(P＜0.05),and the velocity in combined group was faster(P＜0.05),and pulsatility index and resistance index were reduced compared to before treatment(P＜0.05),and the combined group had lower pulsatility index and resistance index(P＜0.05).Conclusion:DNG combined with Guizhi Fuling capsule is more effective than DNG alone in treating EMT,and it can re-duce the levels of serum PAF and TGF-β1,effectively inhibit the inflammatory response,improve the uterine blood flow,control the dis-ease condition and slow down the disease process.

Abstract:Objective:To evaluate the therapeutic effect of fimbriostomy of tubal tube and pelvic adhesion-lysis in combination with tubal fluid drainage on infertile patients with salpingitis.Methods:120 patients with salpingitis obstructive infertility who met the inclusion and exclusion criteria were divided into observation group(n=62)and control group(n=58)according to different treat-ment methods.The control group was treated with tubal drainage,and the observation group was treated with fimbal end ostomy,pelvic adhesion lysis and tubal drainage.The tubal patency rate,clinical pregnancy rate,perioperative sex hormones[luteinizing hormone(LH),follicle-stimulating hormone(FSH),estradiol(E2)],hemorheological indexes[plasma viscosity,low shear viscosity,erythro-cyte sedimentation rate(ESR)]and inflammatory indexes[tumor necrosis factor alpha(TNF-α),C-reactive protein(CRP)],and the incidence of postoperative complications of the two groups before and after treatment were compared.Results:The tubal patency rate and natural pregnancy rate in the observation group were higher than those in the control group,and the ectopic pregnancy rate was lower(P＜0.05).1 month after surgery,compared with the control group,serum LH and FSH concentrations and serum E2 concentrations in the observation group were lower,plasma viscosity,low tangent viscosity,erythrocyte sedimentation rate(ESR)and serum Tumor necro-sis factor(TNF-α)/C-reactive protein(CRP)were lower,and the differences were statistically significant(P＜0.05).There was no significant difference in the postoperative complication rate between the observation group and the control group(P＞0.05).Conclu-sion:Fimbriostomy of tubal tube and pelvic adhesion lysis combined with tubal fluid can effectively repair the pelvic structure,improve inflammation,promote the recovery of gonadal secretion function,improve the tubal patency rate and clinical pregnancy rate.

Abstract:Objective:To analyze the relationship between procalcitonin(PCT)and serum amyloid A(SAA)levels and disease condition and therapeutic effect of patients with brucellosis.Methods:70 patients with brucellosis were enrolled in this study and were divided into mild group(n=34)and severe group(n=36)by means of the disease severity.All patients received standard anti-bru-cellosis treatment.The clinical data of patients with brucellosis were collected,and the levels of PCT and SAA were compared among all patients and between mild group and severe group before and after treatment.Multivariate Logistic regression analysis was used to ana-lyze the risk factors affecting the disease condition and therapeutic effect of patients.Spearman correlation analysis was applied to ana-lyze the relationship of PCT and SAA levels with disease condition and therapeutic effect.Receiver operating characteristic(ROC)curve was adopted to evaluate the predictive ability of serum PCT and SAA levels on disease condition in patients with brucellosis.Re-sults:Before treatment,the PCT and SAA levels in severe group were higher than those in mild group(P＜0.05).After treatment,the levels of PCT and SAA decreased in both groups(P＜0.05),but there was no statistically significant difference between the two groups(P＞0.05).Multivariate Logistic regression analysis indicated that serum PCT and SAA levels were independent risk factors for severi-ty of brucellosis(P＜0.05).Spearman correlation analysis suggested that serum PCT and SAA were positively correlated with brucello-sis severity(P＜0.05),and were negatively correlated with therapeutic effect(P＜0.05).ROC curve analysis showed that the AUCs of serum PCT and SAA levels in the diagnosis of disease severity of brucellosis were 0.781 and 0.866 respectively(P＜0.05).The AUC,sensitivity and specificity of combined diagnosis were 0.934,0.806 and 0.882(P＜0.05).Conclusion:The levels of PCT and SAA are closely related to the disease severity and therapeutic effect of patients with brucellosis,and can be used as important indicators to evaluate the disease condition and therapeutic effect.

Abstract:Objective:To analyze the effect of different doses of low molecular weight heparin combined with nifedipine on se-vere preeclampsia and its effect on oxidative stress in patients.Methods:A total of 102 pregnant women with severe preeclampsia were included and divided into high-dose group(LD group)and low-dose group(SD group)according to different treatment methods,with 51 cases in each group.Both groups were treated with low molecular weight heparin combined with nifedipine on the basis of convention-al treatment,among which the SD group was treated with low molecular weight heparin(2,500 U/time).LD group was treated with high dose of low molecular weight heparin(5,000 U/time).After 1 week of treatment,the clinical efficacy,oxidative stress indicators[superoxide dismutase(SOD),malondialdehyde(MDA),glutathione peroxidase(GSH Px),and protein oxidation products(AOPP)],levels of placental hypoxia cytokines[placental growth factor(PLGF),pregnancy associated plasma protein A(PAPP-A),and soluble endothelial factor(sEng)],and pregnancy outcomes were compared between the two groups.Results:The total effective rate of LD group and SD group was 92.16％and 76.47％,respectively,and LD group was higher than SD group(P＜0.05).There were no significant differences in oxidative stress level and placental hypoxic cytokine expression between the two groups before treat-ment(P＞0.05).SOD,GSH-Px,PLGF and PAPP-A of the two groups after treatment were higher than those before treatment(P＜0.05),and LD group was higher than SD group(P＜0.05).After treatment,MDA,AOPP and sEng in two groups were lower than be-fore treatment(P＜0.05),and LD group was lower than SD group(P＜0.05).The incidence of adverse pregnancy outcomes in LD group and SD group was 11.76％and 29.41％,respectively,and LD group was lower than SD group(P＜0.05).Conclusion:Low molecular weight heparin combined with nifedipine can be effectively applied in the treatment of severe preeclampsia,but the efficacy of different doses of low molecular weight heparin is different.Large doses of low molecular weight heparin are more conducive to impro-ving clinical efficacy,improving maternal oxidative stress and placental hypoxia,and reducing the incidence of adverse pregnancy.

Abstract:Objective:To investigate the influence of group B streptococcus(GBS)infection on vaginal microecology and preg-nancy outcomes in late pregnancy.Methods:Retrospective study on clinical data of late pregnant women who received prenatal vaginal secretion examination were selected for the study.According to the GBS infection detection results,they were divided into GBS positive group(n=71)and GBS negative group(n=49).The vaginal microecological imbalance,vaginal cleanliness grading,delivery modes of pregnant women,adverse pregnancy outcomes of pregnant women and perinatal infants were compared between groups.Results:The incidence rate of bacterial vaginosis(BV),vaginal microecological imbalance rate and proportion of patients with vaginal pH value＞4.6 in GBS positive group were higher than those in GBS negative group(P＜0.05).The proportion of patients with vaginal cleanliness grade 1 in GBS positive group was lower than that in GBS negative group(P＜0.05)while the proportions of patients with grade 3 and grade 4 were higher(P＜0.05).The rate of natural vaginal delivery in GBS positive group was lower(P＜0.05)while the rate of con-version to cesarean section was higher compared with that in GBS negative group(P＜0.05).The incidence rates of adverse pregnancy outcomes of pregnant women(intrauterine infection,premature rupture of membranes,amniotic fluid turbidity/pollution and puerperal infection)and perinatal adverse outcomes(premature birth,low birth weight,pneumonia,GBS infection)were higher in GBS positive group than those in GBS negative group(P＜0.05).Conclusion:GBS infection has a certain impact on vaginal microecological balance and vaginal cleanliness in late pregnancy,which can increase the risk of adverse pregnancy outcomes and perinatal adverse outcomes.

Abstract:Objective:To investigate the clinical efficacy of eperisone combined with imrecoxib in patients undergoing arthro-scopic anterior cruciate ligament reconstruction.Methods:120 patients with anterior cruciate ligament injur were divided into a control group and an observation group according to the different treatment approaches,with 60 cases in each group.All patients underwent ar-throscopic anterior cruciate ligament reconstruction.Post-operatively,the control group was treated with imrecoxib,while the observation group received eperisone in addition to the control group's treatment.Both groups continued their respective treatments for 1 month.The treatment efficiency,first time out of bed,hospitalization time,first time to bend the knee at 90°,pain level,inflammation and knee func-tion of the two groups were recorded and compared.Results:The effective rate of treatment in the observation group was higher than that in the control group(P＜0.05).The levels of first time out of bed,length of hospitalization and time to first 90° knee flexion were low-er in the observation group than in the control group(P＜0.05).Visual Analogue Scale(VAS)scores in both groups decreased at 1,3,and 6 months post-operation compared to pre-treatment levels(P＜0.05),and the observation group was lower than the control group(P＜0.05).Post-treatment levels of high-sensitivity C-reactive protein(hs-CRP),interleukin-6(IL-6),and tumor necrosis factor-α(TNF-α)decreased in both groups,with lower levels observed in the observation group compared to the control group(P＜0.05).In-ternational Knee Documentation Committee(IKDC)subjective scores,Lysholm knee scores,and Tegner activity scores increased in both groups after treatment,with higher scores recorded in the observation group compared to the control group(P＜0.05).Conclu-sion:Treatment with eperisone in combination with imrecoxib promotes postoperative recovery in patients undergoing arthroscopic anteri-or cruciate ligament reconstruction,facilitates the relief of joint pain,helps to reduce the inflammatory response and improves the func-tion of the knee joint,and is recommended for clinical use.

Abstract:Objective:To analyze and compare the differences in dosimetric parameters between two radiotherapy techniques[dynamic intensity modulated radiotherapy(dIMRT)and volumetric modulated arc radiotherapy(VMAT)]for cervical or upper tho-racic esophageal cancer patients,as well as the dose robustness of dIMRT and VMAT under the introduction of 3 mm positioning error.Methods:Selected 22 patients with cervical or upper thoracic esophageal cancer who undergo radical radiotherapy to design a radiother-apy plan.Design dIMRT and VMAT radiotherapy plans simultaneously for each patient,and compare the dose differences between the two radiotherapy plans in the lungs,heart,spinal cord,and other areas.Each technology plan involved translating the treatment center in 6 directions,including the X-axis(left and right),Y-axis(front and back),and Z-axis(head and feet),with a simulated positioning error of 3 mm.The dose distribution of the target area and endangered organs was recalculated,and the changes in the dose distribution of the target area and endangered organs compared to the original plan are observed.Results:Both radiotherapy techniques were able to achieve the prescribed dose in the target area,with high conformability and uniform dose distribution within the target area.Both lungs:For V5,V10,V15,V20,V30,and Dmean,dIMRT was slightly higher than VMAT,and the difference was statistically significant(P＜0.05).Heart:For V20,V30,V40,and Dmean,VMAT was slightly higher than dIMRT,and the difference was statistically signifi-cant(P＜0.05).Under the introduction of 3 mm positioning error,the prescription dose in the target area was not reduced,and the ra-diation dose to organs at risk was also within the dose limit range.The difference in radiation dose and volume between dIMRT and VMAT target areas and surrounding organs at risk was not significant,and the robustness of the two was consistent.Conclusion:When endangering organs,VMAT has a higher radiation dose to the heart than dIMRT,and dIMRT has a higher radiation dose to the lungs,but both are within the dose limit range.DIMRT has fewer machine hops and shorter treatment time for VMAT.When introducing a 3 mm positioning error in the X,Y,and Z axes,left and right,front and back,and head and foot directions,there is little change in the dosime-tric parameters of dIMRT and VMAT,and their robustness is consistent.

Abstract:Objective:To investigate the effects of dextromethorphan guaifenesin syrup combined with azithromycin on myocardi-al enzymes,coagulation function,and inflammation in children with mycoplasma pneumoniae pneumonia.Methods:88 children with my-coplasma pneumonia were divided into a control group and a combination group according to different treatment methods,with 44 cases in each group.The control group received treatment with azithromycin,while the combination group was treated with dextromethorphan guaifenesin syrup in conjunction with azithromycin,with both groups undergoing treatment for 7 days.The clinical symptom relief be-tween the two groups of children after treatment,as well as the levels of myocardial enzyme spectrum and liver function[lactate dehy-drogenase(LDH),creatine kinase(CK),aspartate aminotransferase(AST),alanine aminotransferase(ALT)],coagulation function[D-dimer(D-D)and fibrinogen(Fbg)],and inflammatory indicators[C-reactive protein(CRP),procalcitonin(PCT),neutrophil percentage(NEU),white blood cells(WBC),and platelets(PLT)],along with the treatment efficacy and occurrence of adverse reac-tions were compared between the two groups.Results:The time for the resolution of cough,fever,and lung moist rales in the combined treatment group was shorter than that in the control group(P＜0.05).After treatment,the levels of LDH,CK,AST,and ALT,as well as D-D and Fbg levels,and the levels of CRP,PCT,NEU,WBC,and PLT in both groups of children decreased compared to before treat-ment,with the decrease in the combined treatment group being more pronounced than that in the control group(P＜0.05).The de-crease of Fbg in the combined group was greater than that in the control group,but the difference was not statistically significant(P＞0.05).The treatment efficiency of the combined group was higher than that of the control group(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups of children compared to each other(P＞0.05).Conclusion:The combination of dextromethorphan guaifenesin and azithromycin has shown significant efficacy in treating children with Mycoplasma pneumonia.It can effectively alleviate clinical symptoms,reduce myocardial damage and liver function injury,improve coagulation func-tion,and suppress inflammatory responses,while also demonstrating a high level of safety,making it worthy of clinical promotion and application.

Abstract:Objective:To summarize the strategies for venous protection and key techniques of falx reconstruction during the re-section of parasagittal and falcine meningiomas,thereby improving surgical safety and prognosis.Methods:The Clinical data of 56 pa-tients with parasagittal and falcine meningiomas were retrospectively reviewed.Patients'recovery was assessed via outpatient follow-up.Key technical points for venous protection and falx reconstruction were summarized and discussed alongside literature.Results:All 56 patients recovered well postoperatively,with no mortality.Among them,52 patients showed no hemorrhage or severe cerebral edema on CT scans at approximately 3 hours postoperatively,while 4 had minor hemorrhage.8 patients developed contralateral limb hemiplegia a-round postoperative day 3,and 13 experienced secondary epilepsy,all of which improved with treatment.The preoperative mean KPS score was 81.5±6.7.After 2～3 years of follow-up,the mean KPS score increased to 90.3±5.2.No tumor recurrence,severe paralys-is,or intractable epilepsy was observed.Conclusion:Parasagittal and falcine meningiomas involving the sagittal sinus and deep draining veins require preoperative imaging to clarify tumor-vascular relationships and formulate surgical plans.Intraoperatively,adequate expo-sure of the tumor and surrounding vessels,meticulous protection of draining veins,and reconstruction of the resected falx are critical.These strategies ensure favorable overall outcome.

Abstract:Objective:Using resting state functional magnetic resonance imaging(rs-fMRI)analysis tinnitus cranii and tinnitus local brain function changes and functional connection between brain areas of difference,provide new way for the diagnosis and classifi-cation of tinnitus.Methods:This study included 20 patients with tinnitus cranii,20 patients with tinnitus,and collected their clinical da-ta and RS-fMRI data.The SPM 12 software of Matlab 2021b platform and DPABI 6.3 toolkit were used to analyze the data.The differ-ences of ReHo and FC among the groups were calculated.Results:The ReHo value of the right central sulci in the tinnitus cranii group was higher than that in the tinnitus group(P＜0.005).The functional connections between the left anterior cingulate gyrus and the right inferior temporal gyrus,the right inferior frontal gyrus of the insular cap and the right central sulci gyrus in the tinnitus cranii group were lower than those in the tinnitus group,and the functional connections between the left anterior cuneus and the right superior mar-ginal gyrus in the tinnitus cranii group were lower than those in the tinnitus group.Conclusion:There are differences in neural activity and functional connections between brain regions between tinnitus and tinnitus cranii patients,which may be related to the different spa-tial perception of auditory hallucinations.

Abstract:Objective:To explore the value of high-frequency ultrasound in evaluating adhesion after repair for tendon rupture of hand.Methods:The relevant data of 270 patients with tendon rupture of hand were retrospectively analyzed.According to the postopera-tive functional rehabilitation plan,they were divided into study group(functional rehabilitation based on high-frequency ultrasound,n=150)and control group(conventional functional rehabilitation,n=120).Value of high-frequency ultrasound in postoperative adhesion evaluation,functional rehabilitation exercise and hand function recovery was analyzed.Results:Compared with 1 month after operation,adhesion was improved,PPT scores for dominant hand,bilateral coordination,and assembly tasks were improved,and the MMDT time was significantly shortened at 3 months after operation(P＜0.05).Meanwhile,PPT and MMDT of the study group were significantly better than those of the control group at 3 months after operation(P＜0.05).PPT indicators were negatively correlated with adhesion status(P＜0.05),while MMDT time was positively correlated with adhesion status(P＜0.05).Conclusion:High-frequency ultra-sound can clearly display adhesion in patients with tendon rupture of hand after repair,which is closely related to hand function.The hand function rehabilitation plan developed based on high-frequency ultrasound results can promote hand function recovery.

Abstract:Objective:To explore the risk factors of multi-drug resistant Pseudomonas aeruginosa(MDRPA)infection in diabet-ic foot ulcer(DFU),and to analyze the prognosis status.Methods:296 DFU patients were selected as the study objects,and 99 patients with PA infection(197 patients without PA infection)were divided into MDRPA group(n=54)and non-MDRPA group(n=45)ac-cording to the results of bacterial culture and drug susceptibility test.Univariate analysis and Logistic multivariate analysis were per-formed to analyze the risk factors of MDRPA in patients with DFU,and the prognosis of the two groups was compared.Results:Among 296 patients,320 strains of pathogenic bacteria were cultured,mainly 163 strains of Gram-negative bacteria(50.94％).The drug re-sistance rates of MDRPA to cephalosporins such as ceftazidime,cefepime,piperacillin/tazobactam and ciprofloxacin were＞80％,and the drug resistance rate to levofloxacin was＜70％.The body mass index,proportions of peripheral neuropathy,peripheral vascular dis-ease and osteomyelitis,antibacterial drug type and use time of antibacterial drug in MDRPA group were higher than those in non-MDR-PA group(P＜0.05).Osteomyelitis,hospitalization history of the same ulcer before admission,antibacterial drug type,use time of anti-bacterial drug and Wagner grading were risk factors for MDRPA infection in DFU patients(P＜0.05).Compared with non-MDRPA group,MDRPA group had lower cure rate(P＜0.05)and higher amputation/toe rate(P＜0.05).Conclusion:The main pathogenic bacteria of MDRPA infection in DFU patients is Pseudomonas aeruginosa,which has certain resistance to common antibacterial drugs.The main risk factors for MDRPA infection in DFU patients are osteomyelitis,hospitalization history of the same ulcer before admission,type of antibiotics,duration of antibiotic use and Wagner grade.The prognosis of MDRPA patients is poor.

Abstract:< Zheng > the patient, a 42 year old male, was found to have a tumor on the upper neck near the medial edge of the mandibular angle in October 2023, without conscious pain, tenderness, itching and other discomfort. Color Doppler ultrasound was performed in the 940 Hospital of the joint service support force of the Chinese people's Liberation Army to indicate lymph node enlargement. Considering that it was caused by upper respiratory tract infection, the tumor did not become smaller after taking amoxicillin according to the doctor's advice for half a month, so the drug was stopped automatically. Then he went to the outside hospital for color Doppler ultrasound to suggest a solid space occupying lesion above the left carotid bifurcation. CT showed a 4 cm × 3 cm tumor on the inner side of the left mandibular angle. For further diagnosis and treatment, he went to the 940 Hospital of the joint service support force of the Chinese people's Liberation Army on December 22, 2023.

Abstract:Objective:To explore the effect of vibration training combined with routine exercise rehabilitation nursing on knee proprioception,balance function and joint function recovery in patients after anterior cruciate ligament(ACL)reconstruction.Methods:190 patients after ACL reconstruction were divided into control group and observation group according to different nursing intervention methods,each group had 95 cases.The control group was given routine exercise rehabilitation,and the observation group was given vi-bration training on the basis of routine exercise rehabilitation.Before and 6 weeks after the intervention,the knee joint active angle re-currence test value(AAR),the muscle strength of the affected knee joint muscle group[knee extension and knee flexion peak torque(PT)],Berg scale(BBS)score,fall index,Lysholm score(LKS)and International Knee Documentation Committee(IKDC)score were evaluated.Results:Before the intervention,there was no significant difference in AAR,PT value of knee extension,PT value of knee flexion,BBS score,fall index,LKS score and IKDC score between the two groups(P＞0.05).After 6 weeks of intervention,the knee joint AAR(30 °and 60 °)and fall index of both groups of patients decreased,and the observation group was smaller than the con-trol group(P＜0.05),the PT of knee extension and flexion,BBS score,LKS score,and IKDC score all increased,and the observation group was higher than the control group(P＜0.05).Conclusion:Vibration training combined with routine rehabilitation nursing can improve the proprioception of knee joint,improve the balance function and better restore the function of knee joint in patients with ACL reconstruction.

Abstract:Objective:To explore the effect of nursing intervention model based on empowerment theory on self-care ability,com-plications and quality of life of rectal cancer patients with stoma.Methods:105 patients who underwent rectal cancer ostomy were in-cluded in the study.According to the different nursing methods,they were divided into control group(n=53)and observation group(n=52).The control group was given routine nursing intervention mode,and the observation group was given nursing intervention mode based on authorization theory.The two groups were intervened for 3 months.The levels of knowledge,belief and practice[the knowl-edge,belief and practice scale for enterostomy patients(CPCKAPS)],self-care ability[the self-care ability assessment scale for enter-ostomy],complications,skin conditions around the stoma[the skin assessment tool around the stoma(DET)]and quality of life[the quality of life scale for enterostomy patients(COH-QOL-OQ)]were compared between the two groups.Results:After intervention,the total score of CPCKAPS and the scores of each dimension in the two groups increased(P＜0.05),and the observation group was higher(P＜0.05).The total score and each dimension score of the self-care ability assessment scale of the two groups increased(P＜0.05),and the observation group was higher(P＜0.05).Compared with 18.86％in the control group,the total incidence of complications in the observation group(5.76％)was lower(P＜0.05).The observation group's total score of DET and the scores of each dimension were lower(P＜0.05).After intervention,the score of COH-QOL-OQ in the two groups increased(P＜0.05),and those in the obser-vation group were higher(P＜0.05).Conclusion:The nursing intervention model based on empowerment theory can improve the knowledge-attitude-practice level and self-care ability of patients with rectal cancer stoma,reduce the incidence of complications,protect the skin around the stoma,and improve the quality of life of patients.